The answer to this question depends on what you’re using probiotic supplements for. Many individuals use probiotics on a daily basis to maintain digestive and immune health. In this case, a lower CFU count makes sense and can get the job done. A good range for a daily probiotic is between 5-10 billion CFUs. This can be obtained in the recommended dosage with the Probiotic Pack (tm). So, what about the higher CFU supplements? The higher doses of live cells are optimal for specific ailments or for specific minor health problems.When dealing with specific ailments, 15-45 billion CFUs is a good range. Some specific ailments that may be helped by higher doses of CFUs include Inflammatory Bowel Disease, Irritable Bowel Syndrome, allergies, eczema, and some respiratory illnesses. The higher doses can be obtained by increasing the recommended dosage of the Probiotic Pack(tm).